abstract：:Vascular peroxidase 1 (VPO1) is a member of the peroxidase family which aggravates oxidative stress by producing hypochlorous acid (HOCl). Our previous study demonstrated that VPO1 plays a critical role in endothelial dysfunction through dimethylarginine dimethylaminohydrolase2 (DDAH2)/asymmetric Dimethylarginine (ADM...

journal_title：Redox biology

authors： Liu Z,Liu Y,Xu Q,Peng H,Tang Y,Yang T,Yu Z,Cheng G,Zhang G,Shi R

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Vitamin D status [25(OH)D] has recently been reported to be associated with altered cellular bioenergetic profiles of peripheral blood mononuclear cells (PBMCs). No study has tracked the seasonal variation of 25(OH)D and its putative influence on whole body energy metabolism, cellular bioenergetic profiles, ...

journal_title：Redox biology

authors： Calton EK,Keane KN,Raizel R,Rowlands J,Soares MJ,Newsholme P

更新日期：2017-08-01 00:00:00

abstract：:Heme oxygenase-1 (HO-1) plays a protective role against oxidative stress in plants. The mechanisms regulating its expression, however, remain unclear. Here we studied the methylation state of a GC rich HO-1 promoter region and the expression of several stress-related transcription factors (TFs) in soybean plants subje...

journal_title：Redox biology

authors： Santa-Cruz D,Pacienza N,Zilli C,Pagano E,Balestrasse K,Yannarelli G

更新日期：2017-08-01 00:00:00

abstract：:Many physiological functions of hydrogen sulfide (H2S) have been reported in mammalian cells over the last 20 years. These physiological effects have been ascertained through in vitro treatment of cells with Na2S or NaHS, both of which are precursors of H2S. Since H2S exists as HS- in a neutral solution, a disulfide c...

journal_title：Redox biology

authors： Koike S,Nishimoto S,Ogasawara Y

更新日期：2017-08-01 00:00:00

abstract：:Acute oxygen (O2) sensing is essential for individuals to survive under hypoxic conditions. The carotid body (CB) is the main peripheral chemoreceptor, which contains excitable and O2-sensitive glomus cells with O2-regulated ion channels. Upon exposure to acute hypoxia, inhibition of K+ channels is the signal that tri...

journal_title：Redox biology

authors： Gao L,González-Rodríguez P,Ortega-Sáenz P,López-Barneo J

更新日期：2017-08-01 00:00:00

abstract：:Mouse hindlimb ischemia has been widely used as a model to study peripheral artery disease. Genetic modulation of the enzymatic source of oxidants or components of the antioxidant system reveal that physiological levels of oxidants are essential to promote the process of arteriogenesis and angiogenesis after femoral a...

journal_title：Redox biology

authors： Matsui R,Watanabe Y,Murdoch CE

更新日期：2017-08-01 00:00:00

abstract：:Obesity has grown worldwide over the last few decades. In its different degrees, obesity is accompanied by many clinical and biochemical alterations reflecting the pathological condition of various body tissues. Among the mechanisms underlying the pathogenesis of obesity and associated complications, oxidative stress ...

journal_title：Redox biology

authors： Monzo-Beltran L,Vazquez-Tarragón A,Cerdà C,Garcia-Perez P,Iradi A,Sánchez C,Climent B,Tormos C,Vázquez-Prado A,Girbés J,Estáñ N,Blesa S,Cortés R,Chaves FJ,Sáez GT

更新日期：2017-08-01 00:00:00

abstract：:The notion that oxidative stress plays a role in virtually every human disease and environmental exposure has become ingrained in everyday knowledge. However, mounting evidence regarding the lack of specificity of biomarkers traditionally used as indicators of oxidative stress in human disease and exposures now necess...

journal_title：Redox biology

authors： van 't Erve TJ,Kadiiska MB,London SJ,Mason RP

更新日期：2017-08-01 00:00:00

abstract：:Nitrite and nitrate restore deficient endogenous nitric oxide (NO) production as they are converted back to NO, and therefore complement the classic enzymatic NO synthesis. Circulating nitrate and nitrite must cross membrane barriers to produce their effects and increased nitrate concentrations may attenuate the nitri...

journal_title：Redox biology

authors： Damacena-Angelis C,Oliveira-Paula GH,Pinheiro LC,Crevelin EJ,Portella RL,Moraes LAB,Tanus-Santos JE

更新日期：2017-08-01 00:00:00

abstract：:Endometriosis is a chronic, painful condition with unknown etiology. A differential expression of microRNAs in the endometriotic tissues from women with endometriosis with pain compared to those without suggested a plausible role for miRNA or epigenetic mechanisms in the etiology of endometriotic pain. The peritoneal ...

journal_title：Redox biology

authors： Wright KR,Mitchell B,Santanam N

更新日期：2017-08-01 00:00:00

abstract：:Mitogen-activated protein kinase (MAPK) cascades are evolutionarily conserved modules among eukaryotic species that range from yeast, plants, flies to mammals. In eukaryotic cells, reactive oxygen species (ROS) has both physiological and toxic effects. Both MAPK cascades and ROS signaling are involved in plant respons...

journal_title：Redox biology

authors： Liu Y,He C

更新日期：2017-04-01 00:00:00

abstract：AIMS:Hyperoxic breathing might lead to redox imbalance and signaling changes that affect cerebral function. Paradoxically, hypoxic breathing is also believed to cause oxidative stress. Our aim is to dissect the cerebral tissue responses to altered O2 fractions in breathed air by assessing the redox imbalance and the re...

journal_title：Redox biology

authors： Terraneo L,Paroni R,Bianciardi P,Giallongo T,Carelli S,Gorio A,Samaja M

更新日期：2017-04-01 00:00:00

abstract：:Artesunate, an anti-malarial drug, has been repurposed as an anticancer drug due to its induction of cell death via reactive oxygen species (ROS) production. However, the molecular mechanisms regulating cancer cell death and the resistance of cells to artesunate remain unclear. We investigated the molecular mechanisms...

journal_title：Redox biology

authors： Roh JL,Kim EH,Jang H,Shin D

更新日期：2017-04-01 00:00:00

abstract：:Autophagy is an important cell recycling program responsible for the clearance of damaged or long-lived proteins and organelles. Pharmacological modulators of this pathway have been extensively utilized in a wide range of basic research and pre-clinical studies. Bafilomycin A1 and chloroquine are commonly used compoun...

journal_title：Redox biology

authors： Redmann M,Benavides GA,Berryhill TF,Wani WY,Ouyang X,Johnson MS,Ravi S,Barnes S,Darley-Usmar VM,Zhang J

更新日期：2017-04-01 00:00:00

abstract：:Hydroxytyrosol (HT) is a main phenolic component of olive oil. In this study, we investigated the safety and effects produced by HT purified (99.5%) from olive mill waste. HT was administered at a daily dosage of 45mg for 8 weeks to volunteers with mild hyperlipidemia (n=14). We measured markers of cardiovascular dise...

journal_title：Redox biology

authors： Lopez-Huertas E,Fonolla J

更新日期：2017-04-01 00:00:00

abstract：:The liver has a multitude of functions which are necessary to maintain whole body homeostasis. This requires that various metabolic pathways can run in parallel in the most efficient manner and that futile cycles are kept to a minimum. To a large extent this is achieved due to a functional specialization of the liver ...

journal_title：Redox biology

authors： Kietzmann T

更新日期：2017-04-01 00:00:00

abstract：:Acetaminophen (APAP) hepatotoxicity is characterized by an extensive oxidative stress. However, its source, pathophysiological role and possible therapeutic potential if targeted, have been controversially described. Earlier studies argued for cytochrome P450-generated reactive oxygen species (ROS) during APAP metabol...

journal_title：Redox biology

authors： Du K,Ramachandran A,Jaeschke H

更新日期：2016-12-01 00:00:00

abstract：:Ascorbate (AscH-) functions as a versatile reducing agent. At pharmacological doses (P-AscH-; [plasma AscH-] ≥≈20mM), achievable through intravenous delivery, oxidation of P-AscH- can produce a high flux of H2O2 in tumors. Catalase is the major enzyme for detoxifying high concentrations of H2O2. We hypothesize that se...

journal_title：Redox biology

authors： Doskey CM,Buranasudja V,Wagner BA,Wilkes JG,Du J,Cullen JJ,Buettner GR

更新日期：2016-12-01 00:00:00

abstract：:Mechanistic/mammalian target of rapamycin (mTOR) has emerged as a new potential therapeutic target for gastric cancer. Rapamycin and rapamycin analogs are undergoing clinical trials and have produced clinical responses in a subgroup of cancer patients. However, monotherapy with rapamycin at safe dosage fails to induce...

journal_title：Redox biology

authors： Chen W,Zou P,Zhao Z,Chen X,Fan X,Vinothkumar R,Cui R,Wu F,Zhang Q,Liang G,Ji J

更新日期：2016-12-01 00:00:00

abstract：:Isolated hepatocytes from young (4-6mo) and old (24-26mo) F344 rats were exposed to increasing concentrations of menadione, a vitamin K derivative and redox cycling agent, to determine whether the age-related decline in Nrf2-mediated detoxification defenses resulted in heightened susceptibility to xenobiotic insult. A...

journal_title：Redox biology

authors： Thomas NO,Shay KP,Kelley AR,Butler JA,Hagen TM

更新日期：2016-12-01 00:00:00

abstract：:Simvastatin reduces the blood concentration of cholesterol by inhibiting hydroxymethylglutaryl-coenzyme A reductase, the rate-limiting enzyme in cholesterol synthesis, and thereby reduces the risk of cardiovascular disease. In addition, simvastatin treatment leads to a reduction in fluxes in mitochondrial respiratory ...

journal_title：Redox biology

authors： Rasmussen ST,Andersen JT,Nielsen TK,Cejvanovic V,Petersen KM,Henriksen T,Weimann A,Lykkesfeldt J,Poulsen HE

更新日期：2016-10-01 00:00:00

abstract：:Metabolic control of cellular function is significant in the context of inflammation-induced metabolic dysregulation in immune cells. Generation of reactive oxygen species (ROS) such as hydrogen peroxide and superoxide are one of the critical events that modulate the immune response in neutrophils. When activated, neu...

journal_title：Redox biology

authors： Chacko BK,Wall SB,Kramer PA,Ravi S,Mitchell T,Johnson MS,Wilson L,Barnes S,Landar A,Darley-Usmar VM

更新日期：2016-10-01 00:00:00

abstract：:Redox signaling and oxidative stress are associated with tissue fibrosis and aging. Aging is recognized as a major risk factor for fibrotic diseases involving multiple organ systems, including that of the lung. A number of oxidant generating enzymes are upregulated while antioxidant defenses are deficient with aging a...

journal_title：Redox biology

authors： Kurundkar A,Thannickal VJ

更新日期：2016-10-01 00:00:00

abstract：:Cell-free heme (CFH) and hemoglobin (Hb) have emerged as distinct mediators of acute injury characterized by inflammation and microcirculatory dysfunction in hemolytic conditions and critical illness. Several reports have shown changes in Hb and CFH in specific pathophysiological settings. Using PBS, plasma from patie...

journal_title：Redox biology

authors： Oh JY,Hamm J,Xu X,Genschmer K,Zhong M,Lebensburger J,Marques MB,Kerby JD,Pittet JF,Gaggar A,Patel RP

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Previous studies on oxidative state after partial hepatectomy (PHx) report conflicting data on levels of glutathione (GSH) and are mainly presented in rodent models by methodology less sensitive than the present technologies. The current swine model presents GSH levels and the following genetic response post...

journal_title：Redox biology

authors： Florholmen-Kjær Å,Goll R,Fuskevåg OM,Nygård IE,Paulssen RH,Revhaug A,Mortensen KE

更新日期：2016-10-01 00:00:00

abstract：:The traditional Asian diet is rich in fruits, vegetables and soy, the latter representing a significant source of dietary isoflavones. The isoflavone prunetin was recently identified to improve intestinal epithelial barrier function in vitro and to ameliorate general survival and overall health state in vivo in male D...

journal_title：Redox biology

authors： Piegholdt S,Rimbach G,Wagner AE

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Obstructive Jaundice (OJ) is associated with a significant risk of developing acute renal failure (ARF). The involvement of oxidative stress in the development of cholestasis has been demonstrated in different experimental models. However, its role in the morbidity of human cholestasis is far to be elucidate...

journal_title：Redox biology

authors： Martínez-Cecilia D,Reyes-Díaz M,Ruiz-Rabelo J,Gomez-Alvarez M,Villanueva CM,Álamo J,Muntané J,Padillo FJ

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:The oxidation of the methionine adenosyltransferase (MAT) by the combined impact of peroxides contaminating parenteral nutrition (PN) and oxidized redox potential of glutathione is suspected to explain its inhibition observed in animals. A modification of MAT activity is suspected to be at origin of the PN-a...

journal_title：Redox biology

authors： Elremaly W,Mohamed I,Rouleau T,Lavoie JC

更新日期：2016-08-01 00:00:00

abstract：:Dietary nitrate is now recognized as an alternative substrate for nitric oxide (•NO) production in the gut. This novel pathway implies the sequential reduction of nitrate to nitrite, •NO and other bioactive nitrogen oxides but the physiological relevance of these oxidants has remained elusive. We have previously shown...

journal_title：Redox biology

authors： Rocha BS,Lundberg JO,Radi R,Laranjinha J

更新日期：2016-08-01 00:00:00

abstract：:Mice deficient in the electron transport chain (ETC) complex IV assembly protein SURF1 have reduced assembly and activity of cytochrome c oxidase that is associated with an upregulation of components of the mitochondrial unfolded protein response (UPR(MT)) and increased mitochondrial number. We hypothesized that the u...

journal_title：Redox biology

authors： Pharaoh G,Pulliam D,Hill S,Sataranatarajan K,Van Remmen H

更新日期：2016-08-01 00:00:00

abstract：:Hydrogen sulfide (H2S) is a gaseous signalling molecule involved in many physiological and pathological processes. There is increasing evidence that H2S is implicated in aging and lifespan control in the diet-induced longevity models. However, blood sulfide concentration of naturally long-lived species is not known. H...

journal_title：Redox biology

authors： Dziegelewska M,Holtze S,Vole C,Wachter U,Menzel U,Morhart M,Groth M,Szafranski K,Sahm A,Sponholz C,Dammann P,Huse K,Hildebrandt T,Platzer M

更新日期：2016-08-01 00:00:00

abstract：:Oxidative stress has a critical role in the pathogenesis of Age-related Macular Degeneration (AMD), a multifactorial disease that includes age, gene variants of complement regulatory proteins and smoking as the main risk factors. Stress-induced premature cellular senescence (SIPS) is postulated to contribute to this c...

journal_title：Redox biology

authors： Marazita MC,Dugour A,Marquioni-Ramella MD,Figueroa JM,Suburo AM

更新日期：2016-04-01 00:00:00

abstract：:Vitamin C deficiency globally affects several hundred million people and has been associated with increased morbidity and mortality in numerous studies. In this study, bioavailability of the oxidized form of vitamin C (l-dehydroascorbic acid or DHA)-commonly found in vitamin C containing food products prone to oxidati...

journal_title：Redox biology

authors： Frikke-Schmidt H,Tveden-Nyborg P,Lykkesfeldt J

更新日期：2016-04-01 00:00:00

abstract：:Neuroblastoma is the most common extra-cranial solid tumor in childhood; and patients in stage IV of the disease have a high propensity for tumor recurrence. Retinoid therapy has been utilized as a means to induce differentiation of tumor cells and to inhibit relapse. In this study, the expression of a common neuronal...

journal_title：Redox biology

authors： Silvis AM,McCormick ML,Spitz DR,Kiningham KK

更新日期：2016-04-01 00:00:00

abstract：:There has been some dispute regarding reaction products formed at physiological peroxynitrite fluxes in the nanomolar range with phenolic molecules, when used to predict the behavior of protein-bound aromatic amino acids like tyrosine. Previous data showed that at nanomolar fluxes of peroxynitrite, nitration of these ...

journal_title：Redox biology

authors： Mikhed Y,Bruns K,Schildknecht S,Jörg M,Dib M,Oelze M,Lackner KJ,Münzel T,Ullrich V,Daiber A

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Platelets are essential for maintaining haemostasis and play a key role in the pathogenesis of cardiovascular disease. Upon ligation of platelet receptors through subendothelial matrix proteins, intracellular reactive oxygen species (ROS) are generated, further amplifying the platelet activation response. Th...

journal_title：Redox biology

authors： Carrim N,Arthur JF,Hamilton JR,Gardiner EE,Andrews RK,Moran N,Berndt MC,Metharom P

更新日期：2015-12-01 00:00:00

abstract：:The generation of NO by the various NO synthases in normal and malignant tissues is manifested by various biological effects that are involved in the regulation of cell survival, differentiation and cell death. The role of NO in the cytotoxic immune response was first revealed by demonstrating the induction of iNOS in...

journal_title：Redox biology

authors： Bonavida B,Garban H

更新日期：2015-12-01 00:00:00

abstract：:S-nitrosoglutathione (GSNO) is an endogenous nitric oxide (NO) carrier that plays a critical role in redox based NO signaling. Recent studies have reported that GSNO regulates the activities of STAT3 and NF-κB via S-nitrosylation dependent mechanisms. Since STAT3 and NF-κB are key transcription factors involved in tum...

journal_title：Redox biology

authors： Kaliyaperumal K,Sharma AK,McDonald DG,Dhindsa JS,Yount C,Singh AK,Won JS,Singh I

更新日期：2015-12-01 00:00:00

abstract：:Fibrosis is one of the most prevalent features of age-related diseases like obesity, diabetes, non-alcoholic fatty liver disease, chronic kidney disease, or cardiomyopathy and affects millions of people in all countries. Although the understanding about the pathophysiology of fibrosis has improved a lot during the rec...

journal_title：Redox biology

authors： Richter K,Konzack A,Pihlajaniemi T,Heljasvaara R,Kietzmann T

更新日期：2015-12-01 00:00:00

abstract：:Mitochondria are often regarded as a major source of reactive oxygen species (ROS) in animal cells, with H2O2 being the predominant ROS released from mitochondria; however, it has been recently demonstrated that energized brain mitochondria may act as stabilizers of H2O2 concentration (Starkov et al. [1]) based on the...

journal_title：Redox biology

authors： Treberg JR,Munro D,Banh S,Zacharias P,Sotiri E

更新日期：2015-08-01 00:00:00